Mast cells in the pathogenesis of chronic back pain: a hypothesis

被引：46

作者：

Freemont, AJ ^{[1
]}

Jeziorska, M ^{[1
]}

Hoyland, JA ^{[1
]}

Rooney, P ^{[1
]}

Kumar, S ^{[1
]}

机构：

[1] Univ Manchester, Sch Med, Musculoskeletal Res Grp, Manchester M13 9PT, Lancs, England

来源：

JOURNAL OF PATHOLOGY | 2002年 / 197卷 / 03期

关键词：

mast cells; nerve fibres; nerve growth factor; angiogenesis; chronic low back pain; intervertebral disc;

D O I：

10.1002/path.1107

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The pathophysiology of chronic low back pain:is poorly understood, mainly because it is difficult to study experimentally or objectively. Recently it has been found that there is a relationship between neovascularization and innervation of the usually avascular and aneural intervertebral disc at the sites of discogenic pain. These data. together with the recognized involvement of mast cells in tissue repair, in the induction of angiogenesis, and in the production of and response to neurotrophic stimuli such as nerve growth factor, has suggested the hypothesis that mast cells may have a causative role in chronic low back pain. If so, the mast cell may represent an attractive therapeutic target. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：281 / 285

页数：5

共 36 条

[1]

NEUROPEPTIDE-Y, TYROSINE-HYDROXYLASE AND VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NERVE-FIBERS IN THE VERTEBRAL BODIES, DISKS, DURA-MATER, AND SPINAL LIGAMENTS OF THE RAT LUMBAR SPINE [J].