Glucocorticoids in rheumatoid arthritis - Effects on erosions and bone

被引：28

作者：

Bijlsma, JWJ ^{[1
]}

Van Everdingen, AA ^{[1
]}

Huisman, M ^{[1
]}

De Nijs, RNJTL ^{[1
]}

Jacobs, JWG ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Dept Rheumatol & Clin Immunol, NL-3508 GA Utrecht, Netherlands

来源：

NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS | 2002年 / 966卷

关键词：

glucocorticoids; rheumatoid arthritis; erosions; bone;

D O I：

10.1111/j.1749-6632.2002.tb04205.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, four prospective placebo-controlled studies have further evaluated the disease-modifying properties of glucocorticoids in the treatment of rheumatoid arthritis. These studies irrefutably show that the use of (low) doses of glucocorticoids leads to a significant retardation of the progression of erosions, especially in early rheumatoid arthritis. This effect on erosions seems more impressive and probably more persistent than the well-known relief during low-dose glucocorticoid therapy of symptoms, such as pain, stiffness, and joint scores. The management of the (side) effects of glucocorticoids on bone has clearly improved in the last years. These two developments lead to a further optimizing of glucocorticoid treatment in patients with rheumatoid arthritis.

引用

页码：82 / 90

页数：9

共 21 条

[1]

BERCZI I, 1987, BRIT J RHEUMATOL, V26, P433

[2] CORTICOSTEROIDS IN RHEUMATOID-ARTHRITIS - HOW BEST TO USE THEM [J].

BIJLSMA, JWJ ;

VANEVERDINGEN, AA ;

JACOBS, JWG .

CLINICAL IMMUNOTHERAPEUTICS, 1995, 3 (04) :271-286

[3] Hormonal preservation of bone in rheumatoid arthritis [J].

Bijlsma, JWJ ;

Jacobs, JWG .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2000, 26 (04) :897-+

[4] Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis [J].

Boers, M ;

Verhoeven, AC ;

Markusse, HM ;

vandeLaar, MAFJ ;

Westhovens, R ;

vanDenderen, JC ;

vanZeben, D ;

Dijkmans, BAC ;

Peeters, AJ ;

Jacobs, P ;

vandenBrink, HR ;

Schouten, HJA ;

vanderHeijde, DMFM ;

Boonen, A ;

vanderLinden, S .

LANCET, 1997, 350 (9074) :309-318

[5]

BOIJMPAS DT, 1993, ANN INTERN MED, V119, P1198

[6]

Buckley L, 2001, ARTHRITIS RHEUM, V44, P1496

[7]

Cunnane G, 2001, ARTHRITIS RHEUM-US, V44, P1744, DOI 10.1002/1529-0131(200108)44:8<1744::AID-ART309>3.0.CO

[8]

2-K

[9]

Da Silva JAP, 2000, RHEUM DIS CLIN N AM, V26, P859

[10] Prevalence of vertebral deformities and symptomatic vertebral fractures in corticosteroid treated patients with rheumatoid arthritis [J].

de Nijs, RNJ ;

Jacobs, JWG ;

Bijlsma, JWJ ;

Lems, WF ;

Laan, RFJM ;

Houben, HHM ;

ter Borg, EJ ;

Huisman, AM ;

Bruyn, GAW ;

van Oijen, PLM ;

Westgeest, AAA ;

Algra, A ;

Hofman, DM .

RHEUMATOLOGY, 2001, 40 (12) :1375-1383

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