Fos-like immunoreactivity in locus coeruleus after classical conditioning of the rabbit's nictitating membrane response

被引:9
作者
Carrive, P
Kehoe, J
Macrae, M
Paxinos, G
机构
[1] School of Psychology, University of New South Wales, Sydney
基金
澳大利亚研究理事会;
关键词
locus coeruleus; lateral paragigantocellular nucleus; fos; nictitating membrane; classical conditioning; attention; learning;
D O I
10.1016/S0304-3940(97)13395-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated the changes in Fos-like immunoreactivity in the locus coeruleus (LC) after classical conditioning of the rabbit's nictitating membrane. Specifically, we compared unpaired versus paired presentations of a tone conditioned stimulus (CS) and a tactile unconditioned stimulus (US; near the eye). After two training sessions, only paired presentations resulted in acquisition of a conditioned response. This was associated with comparatively less LC Fos expression than with unpaired presentations. Similar observations have been reported for the ventrolateral medulla which is a major source of afferents to LC. The present results are consistent with a role of LC in attention and learning: activity increases as the animal attends to the CS and US. When the relationship between CS and US has been established, LC activity decreases. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:33 / 36
页数:4
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