Angiotensin-converting enzyme and cardiovascular disease risk

被引：19

作者：

O'Malley, JP ^{[1
]}

Maslen, CL ^{[1
]}

Illingworth, DR ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1097/00041433-199910000-00005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The published studies of the association of the angiotensin-converting enzyme (ACE) genotype with cardiovascular disease have used many different diagnostic criteria for cardiovascular disease and have drawn their samples from different patient groups and different populations. This review examines the association of the ACE DD genotype with cardiovascular disease risk in studies grouped by their case criterion, the geographical region of the population samples, and by the cardiovascular risk level of the patient sample. In studies where the underlying odds ratios are determined to be homogeneous, the overall odds ratios for myocardial infarction and coronary artery disease with regard to the ACE DD genotype are estimated using the Mantel-Haenszel method. Curr Opin Lipidol 10:407-415. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：407 / 415

页数：9

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