Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution

被引：30

作者：

Oliviero, G

Borbone, N

Galeone, A

Varra, M

Piccialli, G

Mayol, L

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, Fac Sci Biotecnnol, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, Fac Farm, I-80131 Naples, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 25期

关键词：

DNA; quadruplex; G-quartets; solid-phase synthesis;

D O I：

10.1016/j.tetlet.2004.04.149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cluster of four d(TG(4)T) hexanucleotides with the 3'-ends linked together by a bunchy spacer has been synthesized and shown to form a monomolecular parallel quadruplex 5 in solution characterized by four G-quartets. H-1 NMR spectroscopy and CD thermal denaturation experiments indicate the monomolecular quadruplex (5) to be more stable than the tetramolecular counterpart [d(TG(4)T)](4). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4869 / 4872

页数：4

共 33 条

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