Antenatal invasive and noninvasive management of alloimmune thrombocytopenia

被引：15

作者：

Kornfeld, I ^{[1
]}

Wilson, RD ^{[1
]}

Ballem, P ^{[1
]}

Wittmann, BK ^{[1
]}

Farquharson, DF ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, DEPT MATERNAL FETAL MED, BRITISH COLUMBIA WOMENS HOSP, VANCOUVER, BC V6H 3V5, CANADA

来源：

FETAL DIAGNOSIS AND THERAPY | 1996年 / 11卷 / 03期

关键词：

alloimmune thrombocytopenia; cordocentesis; intravenous immunoglobulin;

D O I：

10.1159/000264304

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The outcome analysis of 10 pregnancies at risk for neonatal alloimmune thrombocytopenia (NAIT) is presented. An experimental protocol of cordocentesis and maternal administration of intravenous immunoglobulin (IVIG) is compared to a control group of older untreated affected siblings, The outcome in pregnancies treated with IVIG shows improved fetal platelet count in 70% and no intraventricular hemorrhage, We conclude that maternal administration of IVIG appears to improve clinical outcome in fetuses at risk for NAIT.

引用

页码：210 / 217

页数：8

共 46 条

[1]

BLANCHETTE VS, 1988, CURR STUD HEMATOL BL, V55, P87

[2] NEONATAL ALLOIMMUNE THROMBOCYTOPENIA - SPONTANEOUS IN UTERO INTRACRANIAL HEMORRHAGE [J].