Breast cancer prognostic significance of some modified urinary nucleosides

被引：74

作者：

Sasco, AJ

Rey, F

Reynaud, C

Bobin, JY

Clavel, M

Niveleau, A

机构：

[1] INSERM,F-69008 LYON,FRANCE

[2] INST PASTEUR,CNRS,URA 1459,F-69365 LYON 07,FRANCE

[3] CTR HOSP LYON SUD,SERV CHIRURG ONCOL,F-69495 PIERRE BENITE,FRANCE

[4] CTR LEON BERARD,MED ONCOL SERV,F-69373 LYON 08,FRANCE

来源：

CANCER LETTERS | 1996年 / 108卷 / 02期

关键词：

breast cancer; modified nucleosides; urinary excretion; prognosis;

D O I：

10.1016/S0304-3835(96)04393-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognostic significance of six urinary modified nucleosides, 5-methylcytidine (5-MeCyd), 4-acetylcytidine (4-AcCyd), 1methylinosine (1-MeIno), 1-methyladenosine (1-MeAdo), 7-methylguanosine (7-MeGua) and pseudouridine (Psi-Urd) was evaluated in 68 breast cancer patients of the specialized cancer hospital of Lyon (France). Excretions of 1-MeIno and 1-MeAdo were significantly higher in patients hospitalized in the medical rather than surgical ward, reflecting more advanced disease, and also among patients who died within 5 years of follow-up as compared to those still dye. These results suggest an unfavourable prognostic significance of high urinary excretion of 1-MeIno and 1-MeAdo in breast cancer patients.

引用

页码：157 / 162

页数：6

共 22 条

[1]

[Anonymous], 1977, Statistical Methods in Medical Research

[2]

BOREK E, 1983, CANCER DETECT PREV, V6, P67

[3]

Borek E, 1972, Adv Cancer Res, V15, P163, DOI 10.1016/S0065-230X(08)60374-7

[4]

BOREK E, 1983, RECENT RES CANCER, V84, P301