Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics

被引：20

作者：

Halkes, SBA ^{[1
]}

Vrasidas, I ^{[1
]}

Rooijer, GR ^{[1
]}

van den Berg, AJJ ^{[1
]}

Liskamp, RMJ ^{[1
]}

Pieters, RJ ^{[1
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00245-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Inspired by the structure of tannic acid, first- to third-generation dendrimers containing two, four, and eight galloyl moieties were synthesized. Stability, antioxidant activity and collagen cross-linking activity of the natural product and its dendrimer analogues were compared. The experimental results indicate that polygalloyl dendrimers might be used as new lead compounds to improve the long-term healing characteristics of burn wounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1567 / 1570

页数：4

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