The biology of PGC-1α and its therapeutic potential

被引：125

作者：

Handschin, Christoph ^{[1
,2
,3
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[2] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

[3] Univ Zurich, Zurich Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2009年 / 30卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; RECEPTOR-GAMMA COACTIVATOR-1-ALPHA; MUSCLE MITOCHONDRIAL-FUNCTION; ENERGY-METABOLISM; SKELETAL-MUSCLE; HEPATIC GLUCONEOGENESIS; HUNTINGTONS-DISEASE; INSULIN-RESISTANCE; PPAR-ALPHA; OXIDATIVE-PHOSPHORYLATION;

D O I：

10.1016/j.tips.2009.03.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

In eukaryotes, cellular and. systemic metabolism is primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor gamma coactivator let (PGC-1 alpha) is an important regulator of mitochondrial biogenesis and function. Furthermore, PGC-1 alpha controls many of the phenotypic adaptations of oxidative tissues to external and internal perturbations. By contrast, dysregulated metabolic plasticity is involved in the etiology of numerous diseases. Accordingly, modulation of PGC-1 alpha levels and activity has recently been proposed as a therapeutic option for several pathologies. However, pharmacological interventions aimed at PGC-1 alpha have to overcome inherent limitations of targeting a coactivator protein. Here, I focus on the recent breakthroughs in the identification of physiological and pathophysiological contexts involving PGC-1 alpha. In addition, perspectives regarding the therapeutic importance of PGC-1 alpha-controlled cellular and systemic metabolism are outlined.

引用

收藏

页码：322 / 329

页数：8

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