Ring-based analogues of pentamidine versus P-carinii pneumonia in culture

被引：7

作者：

Delia, TJ

Nagarajan, A

Queener, SF

Bartlett, MS

机构：

[1] INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,INDIANAPOLIS,IN 46205

[2] INDIANA UNIV,SCH MED,DEPT LAB MED & PATHOL,INDIANAPOLIS,IN 46205

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 19期

关键词：

D O I：

10.1016/0960-894X(96)00427-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of aromatic ring-based pentamidine analogues, in which the aliphatic bridge has been replaced by benzene, pyridine, or pyrimidine has been accomplished in two steps. Compounds containing benzene and pyridine as the central core of the molecule have demonstrated activity against PCP in culture. Copyright (C) 1996 Elsevier Science Ltd

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页码：2367 / 2370

页数：4

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