Antioxidant properties of cabergoline: inhibition of brain auto-oxidation and superoxide anion production of microglial cells in rats

被引：14

作者：

Yoshida, T ^{[1
]}

Tanaka, M ^{[1
]}

Suzuki, Y ^{[1
]}

Sohmiya, M ^{[1
]}

Okamoto, K ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 330卷 / 01期

关键词：

cabergoline; alpha-tocopherol; microglial cells; Parkinson's disease; 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one-dependent chemiluminescence assay; phorbol myristate acetate; opsonized zymosan;

D O I：

10.1016/S0304-3940(02)00594-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluated the effect of cabergoline on superoxide anion production by rat microglial cells using a 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1, 2-a]pyrazin-3-one-dependent chemiluminescence assay. Cabergoline dose-dependently inhibited superoxide anion production by microglial cells stimulated with phorbol myristate acetate or opsonized zymosan, while it had no superoxide dismutase-like activity. We also studied the effects of cabergoline and alpha-tocopherol on thiobarbituric acid reactive substances formation in homogenized brain-tissue in rats. Cabergoline was stronger than alpha-tocopherol in inhibiting auto-oxidation. While cabergoline is commonly used to treat the motor dysfunction of Parkinson's disease, it may also be effective in inhibiting oxidative stress, a possible mechanism of dopaminergic neuronal degeneration in Parkinson's disease. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

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