Stable chromosomal inversion Polymorphisms and insecticide resistance in the malaria vector mosquito Anopheles gambiae (Diptera: Culicidae)

被引:35
作者
Brooke, BD [1 ]
Hunt, RH
Chandre, F
Carnevale, P
Coetzee, M
机构
[1] Natl Hlth Lab Serv, Sch Pathol, Dept Clin Microbiol & Infect Dis, Johannesburg, South Africa
[2] Univ Witwatersrand, Dept Anim Plant & Environm Sci, Johannesburg, South Africa
[3] Inst Pierre Richet, OCCGE, Bouake, Cote Ivoire
关键词
Anopheles gambiae; chromosome inversions; heterosis; insecticide resistance; Mali; Cote d'Ivoire;
D O I
10.1603/0022-2585-39.4.568
中图分类号
Q96 [昆虫学];
学科分类号
摘要
Anopheles gambiae Giles has been implicated as a major vector of malaria in Africa. A number of paracentric chromosomal inversions have been observed as polymorphisms in wild and laboratory populations of this species. These polymorphisms have been used to demonstrate the existence of five reproductive units in West African populations that are currently described as incipient species. They have also been correlated with various behavioral characteristics such as adaptation to aridity and feeding preference and have been associated with insecticide resistance. Two paracentric inversions namely 2La and 2Rb are highly ubiquitous in the wild and laboratory populations sampled. Both inversions are easily conserved during laboratory colonization of wild material and one shows significant positive heterosis with respect to Hardy-Weinberg proportions. Inversion 2La has previously been associated with dieldrin resistance and inversion 2Rb shows an association with DDT resistance based on this study. The stability and maintenance of these inversions as polymorphisms provides an explanation for the transmission and continued presence of DDT and dieldrin resistance in a laboratory strain of An. gambiae in the absence of insecticide selection pressure. This effect may also be operational in wild populations. Stable inversion polymorphism also provides a possible mechanism for the continual inheritance of suitable genetic factors that otherwise compromise the fitness of genetically modified malaria vector mosquitoes.
引用
收藏
页码:568 / 573
页数:6
相关论文
共 30 条
[1]   A new marker, black, a useful recombination suppressor, in(2)2, and a balanced lethal for chromosome 2 of the mosquito Anopheles gambiae [J].
Benedict, MQ ;
McNitt, LM ;
Cornel, AJ ;
Collins, FH .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (04) :618-624
[2]  
Brogdon WG, 1998, J AM MOSQUITO CONTR, V14, P159
[3]   Resistance to dieldrin plus fipronil assorts with chromosome inversion 2La in the malaria vector Anopheles gambiae [J].
Brooke, BD ;
Hunt, RH ;
Coetzee, M .
MEDICAL AND VETERINARY ENTOMOLOGY, 2000, 14 (02) :190-194
[4]  
Chandre F, 1999, PARASSITOLOGIA, VOL 41, NOS 1-3, SEPTEMBER 1999, P319
[5]   CHROMOSOMAL INVERSION INTERGRADATION AND INCIPIENT SPECIATION IN ANOPHELES-GAMBIAE [J].
COLUZZI, M ;
PETRARCA, V ;
DIDECO, MA .
BOLLETTINO DI ZOOLOGIA, 1985, 52 (1-2) :45-63
[6]   BEHAVIORAL DIVERGENCES BETWEEN MOSQUITOS WITH DIFFERENT INVERSION KARYOTYPES IN POLYMORPHIC POPULATIONS OF ANOPHELES-GAMBIAE COMPLEX [J].
COLUZZI, M ;
SABATINI, A ;
PETRARCA, V ;
DIDECO, MA .
NATURE, 1977, 266 (5605) :832-833
[7]   CHROMOSOMAL DIFFERENTIATION AND ADAPTATION TO HUMAN ENVIRONMENTS IN THE ANOPHELES-GAMBIAE COMPLEX [J].
COLUZZI, M ;
SABATINI, A ;
PETRARCA, V ;
DIDECO, MA .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1979, 73 (05) :483-497
[8]  
Davidson G, 1967, GENETICS INSECT VECT, P211
[9]  
della Torre A, 2001, INSECT MOL BIOL, V10, P9, DOI 10.1046/j.1365-2583.2001.00235.x
[10]  
DOBZHANSKY T, 1947, GENETICS, V32, P142