Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA

被引：55

作者：

Goldstone, AP ^{[1
]}

Morgan, I

Mercer, JG

Morgan, DGA

Moar, KM

Ghatei, MA

Bloom, SR

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Endocrine Unit, London W12 0NN, England

[2] Rowett Res Inst, Mol Neuroendocrinol Unit, Aberdeen AB21 9SB, Scotland

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 269卷 / 02期

基金：

英国医学研究理事会;

关键词：

leptin; GLP-1; feeding; starvation; hypothalamus; brain stem; nucleus of the solitary tract;

D O I：

10.1006/bbrc.2000.2288

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin, the adipocyte-derived plasma hormone, and CNS GLP-1 neurons reduce food intake and body weight. GLP-1 is produced in the CNS by posttranslational processing of pre-proglucagon. ICV leptin administration prevented the reduction in hypothalamic GLP-1 peptide content seen in pair-fed food-restricted rats (P < 0.05). There was a significant overall positive correlation between pre-proglucagon mRNA expreession in the NTS and hypothalamic GLP-1 peptide content (r = +0.34, P < 0.05). Intraperitoneal leptin administration also increased hypothalamic GLP-1 peptide in food-restricted mice (P < 0.05). This supports the hypothesis that the anorectic actions of leptin are in part due to stimulation of GLP-1 neurons. Reduced CNS GLP-1 neuronal; activity during food deprivation may act to stimulate feeding behaviour, and perhaps also inhibit hypothalamic LHRH neurons, as part of the neuroendocrine response to starvation. (C) 2000 Academic Press.

引用

页码：331 / 335

页数：5

共 26 条

[1] Role of leptin in the neuroendocrine response to fasting [J].

Ahima, RS ;

Prabakaran, D ;

Mantzoros, C ;

Qu, DQ ;

Lowell, B ;

MaratosFlier, E ;

Flier, JS .

NATURE, 1996, 382 (6588) :250-252

[2] Metabolic control of sexual function and growth: Role of neuropeptide Y and leptin [J].

Aubert, ML ;

Pierroz, DD ;

Gruaz, NM ;

d'Alleves, V ;

Vuagnat, BAM ;

Pralong, FP ;

Blum, WF ;

Sizonenko, PC .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1998, 140 (1-2) :107-113

[3] Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line [J].

Beak, SA ;

Heath, MM ;

Small, CJ ;

Morgan, DGA ;

Ghatei, MA ;

Taylor, AD ;

Buckingham, JC ;

Bloom, SR ;

Smith, DM .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (06) :1334-1341

[4] Unraveling the central nervous system pathways underlying responses to leptin [J].

Elmquist, JK ;

Maratos-Flier, E ;

Saper, CB ;

Flier, JS .

NATURE NEUROSCIENCE, 1998, 1 (06) :445-450

[5] Endocrine function of neuropeptide Y knockout mice [J].

Erickson, JC ;

Ahima, RS ;

Hollopeter, G ;

Flier, JS ;

Palmiter, RD .

REGULATORY PEPTIDES, 1997, 70 (2-3) :199-202

[6] Leptin and the regulation of body weight in mammals [J].

Friedman, JM ;

Halaas, JL .

NATURE, 1998, 395 (6704) :763-770

[7] Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents [J].

Goldstone, AP ;

Mercer, JG ;

Gunn, I ;

Moar, KM ;

Edwards, CMB ;

Rossi, M ;

Howard, JK ;

Rasheed, S ;

Turton, MD ;

Small, C ;

Heath, MM ;

OShea, D ;

Steere, J ;

Meeran, K ;

Ghatei, MA ;

Hoggard, N ;

Bloom, SR .

FEBS LETTERS, 1997, 415 (02) :134-138

[8]

GUDMUNDSSON K, 1999, 81 ANN M END SOC OR3

[9] Central glucagon-like peptide-1 in the control of feeding [J].

Gunn, I ;

OShea, D ;

Turton, MD ;

Beak, SA ;

Bloom, SR .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1996, 24 (02) :581-584

[10]

Håkansson ML, 1998, J NEUROSCI, V18, P559

← 1 2 3 →