Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors

被引：80

作者：

Casimiro, DR

Bett, AJ

Fu, TM

Davies, ME

Tang, AM

Wilson, KA

Chen, MC

Long, R

McKelvey, T

Chastain, M

Gurunathan, S

Tartaglia, J

Emini, EA

Shiver, J

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Viral Vaccine Res, W Point, PA 19486 USA

[2] Aventis Pasteur Inc, Swiftwater, PA USA

[3] Aventis Pasteur Ltd, Toronto, ON, Canada

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 20期

关键词：

D O I：

10.1128/JVI.78.20.11434-11438.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective adenovirus serotype 5 (Ad5) or poxvirus vectors, used either alone or in combination with each other. The responses arising from a heterologous Ad5 priming-poxvirus boosting regimen were significantly greater than those elicited by homologous regimens with the individual vectors or by a heterologous poxvirus priming-Ad5 boosting regimen. The heterologous Ad5 priming-poxvirus boosting approach may have potential utility in humans as a means of inducing high levels of cellular immunity.

引用

页码：11434 / 11438

页数：5

共 23 条

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