The neuropsychiatric profile of Addison's disease: Revisiting a forgotten phenomenon

被引:52
作者
Anglin, Rebecca E.
Rosebush, Patricia I.
Mazurek, Michael F.
机构
[1] McMaster Univ, Dept Med, Hamilton, ON L8S 4L8, Canada
[2] McMaster Univ, Dept Psychiat & Behav Sci, Hamilton, ON L8S 4L8, Canada
[3] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8S 4L8, Canada
关键词
D O I
10.1176/appi.neuropsych.18.4.450
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
One hundred fifty years since Thomas Addison's original description of the disease, it is not commonly appreciated that patients with Addison's disease may present with psychiatric symptoms. A review of the literature indicates that disturbances in mood, motivation, and behavior are associated with Addison's disease. Psychosis occurs less frequently, but can be the presenting symptom of a life-threatening adrenal crisis. Potential mechanisms for the neuropsychiatric symptoms of Addison's disease include electrophysiological, electrolyte and metabolic abnormalities, glucocorticoid deficiency, increased endorphins, and an associated Hashimoto encephalopathy. Physicians must be aware that Addison's disease may present solely with psychiatric symptoms and maintain a high index of suspicion for this potentially fatal condition.
引用
收藏
页码:450 / 459
页数:10
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