Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial

被引：182

作者：

Boussi-Gross, Rahav ^{[1
]}

Golan, Haim ^{[3
,4
]}

Fishlev, Gregori ^{[1
]}

Bechor, Yair ^{[1
]}

Volkov, Olga ^{[3
,4
]}

Bergan, Jacob ^{[1
]}

Friedman, Mony ^{[1
]}

Hoofien, Dan ^{[6
,7
]}

Shlamkovitch, Nathan ^{[8
]}

Ben-Jacob, Eshel ^{[2
,5
,9
,10
]}

Efrati, Shai ^{[1
,2
,3
,10
]}

机构：

[1] Assaf Harofeh Med Ctr, Inst Hyperbar Med, IL-70300 Zerifin, Israel

[2] Assaf Harofeh Med Ctr, Res & Dev Unit, IL-70300 Zerifin, Israel

[3] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[4] Assaf Harofeh Med Ctr, Inst Nucl Med, IL-70300 Zerifin, Israel

[5] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Phys & Astron, IL-69978 Tel Aviv, Israel

[6] Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel

[7] Natl Inst Rehabil Brain Injured, Tel Aviv, Israel

[8] Assaf Harofeh Med Ctr, IL-70300 Zerifin, Israel

[9] Rice Univ, Ctr Theoret Biol Phys, Houston, TX USA

[10] Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv, Israel

来源：

PLOS ONE | 2013年 / 8卷 / 11期

关键词：

EMISSION COMPUTED-TOMOGRAPHY; ACUTE ISCHEMIC-STROKE; MINOR HEAD-INJURY; DEAD-SEA; LOW-ALTITUDE; NEUROPSYCHOLOGICAL DEFICITS; MITOCHONDRIAL-FUNCTION; CEREBRAL OXYGENATION; CINGULATE GYRUS; TISSUE OXYGEN;

D O I：

10.1371/journal.pone.0079995

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Traumatic brain injury (TBI) is the leading cause of death and disability in the US. Approximately 70-90% of the TBI cases are classified as mild, and up to 25% of them will not recover and suffer chronic neurocognitive impairments. The main pathology in these cases involves diffuse brain injuries, which are hard to detect by anatomical imaging yet noticeable in metabolic imaging. The current study tested the effectiveness of Hyperbaric Oxygen Therapy (HBOT) in improving brain function and quality of life in mTBI patients suffering chronic neurocognitive impairments.

引用

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