Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

被引:130
作者
Toshikuni, Nobuyuki [1 ]
Tsutsumi, Mikihiro [2 ]
Arisawa, Tomiyasu [1 ]
机构
[1] Kanazawa Med Univ, Dept Gastroenterol, Uchinada, Ishikawa 9200293, Japan
[2] Kanazawa Med Univ, Dept Hepatol, Uchinada, Ishikawa 9200293, Japan
关键词
Alcoholic liver disease; Nonalcoholic fatty liver disease; Clinical characteristics; Outcomes; Chronic liver disease; ATTENUATION PARAMETER CAP; TERM-FOLLOW-UP; CARBOHYDRATE-DEFICIENT TRANSFERRIN; SIMPLE NONINVASIVE INDEX; LONG-TERM; HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; RISK-FACTORS; NATURAL-HISTORY; FIBROSIS PROGRESSION;
D O I
10.3748/wjg.v20.i26.8393
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are serious health problems worldwide. These two diseases have similar pathological spectra, ranging from simple hepatic steatosis to steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. Although most subjects with excessive alcohol or food intake experience simple hepatic steatosis, a small percentage of individuals will develop progressive liver disease. Notably, both ALD and NAFLD are frequently accompanied by extrahepatic complications, including cardiovascular disease and malignancy. The survival of patients with ALD and NAFLD depends on various disease-associated conditions. This review delineates the clinical characteristics and outcomes of patients with ALD and NAFLD by comparing their epidemiology, the factors associated with disease susceptibility and progression, and the predictors and characteristics of outcomes. A comprehensive understanding of the characteristics and outcomes of ALD and NAFLD is imperative in the management of these chronic liver diseases. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码:8393 / 8406
页数:14
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