Key role of Kruppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias

Purpose of review To describe recent studies on Kruppel-like factor transcription factors and their relationship with gastrointestinal neoplasias, in particular pancreatic cancer. Recent findings Kruppel-like factor proteins are a subfamily of transcription factors characterized by the presence of a conserved DNA-binding domain comprising three Kruppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes including cell growth and differentiation. Recently, a number of publications have provided evidence of the implication of Kruppel-like factor proteins in gastrointestinal carcinogenesis. Summary This article will focus on the results of studies in the field published in the last year.