Colon cancer is induced by a single low dose of azoxymethane in fasted-refed rats

被引:6
作者
Caderni, G
Bollito, E
Tessitore, L
机构
[1] Univ Turin, Osped Luigi Gonzaga, Dipartimento Sci Clin & Biol, Sez Istol & Anat Patol, I-10043 Turin, Italy
[2] Univ Florence, Dipartimento Farmacol, Florence, Italy
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1999年 / 35卷 / 02期
关键词
D O I
10.1207/S15327914NC352_7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We reported previously that fasting-refeeding enhanced the growth of preneoplastic lesions in the colon of rats induced by 20 mg/kg of azoxymethane (AOM). Here we studied whether fasting-refeeding could also affect I) the induction of colon cancer by the same dose of AOM and 2) the induction of foci by lower doses of AOM that do not induce foci in fully fed rats. Fully fed and fasted-refed rats were given AOM by single subcutaneous injection, and the development of foci or tumors was evaluated three months or one year later. The results of the long-term carcinogenesis experiments showed that the total incidence of tumors was increased in the fasted-refed rats. Moreover, although fully fed rats developed foci only when injected with 7.5, 10, or 20 mg/kg of the carcinogen, a significant number of foci were also induced by 5 mg/kg in fasted-refed rats. The crypt multiplicity of foci was also higher when rats were exposed to fasting-refeeding, even when the number of foci was unchanged. These data suggest that growth perturbations induced by fasting-refeeding lead to the development of preneoplastic lesions with doses of AOM too low to trigger foci in fully fed rats and produce enhanced sensitivity to the development of intestinal tumors.
引用
收藏
页码:137 / 142
页数:6
相关论文
共 32 条
[1]   OBSERVATION AND QUANTIFICATION OF ABERRANT CRYPTS IN THE MURINE COLON TREATED WITH A COLON CARCINOGEN - PRELIMINARY FINDINGS [J].
BIRD, RP .
CANCER LETTERS, 1987, 37 (02) :147-151
[2]  
CUNANNE SC, 1992, AM J PHYSIOL, V262, pR8
[3]  
Farber E, 1980, Adv Cancer Res, V31, P125, DOI 10.1016/S0065-230X(08)60658-2
[4]  
FARBER E, 1987, LAB INVEST, V56, P4
[5]   FOOD RESTRICTION ELIMINATES PRENEOPLASTIC CELLS THROUGH APOPTOSIS AND ANTAGONIZES CARCINOGENESIS IN RAT-LIVER [J].
GRASLKRAUPP, B ;
BURSCH, W ;
RUTTKAYNEDECKY, B ;
WAGNER, A ;
LAUER, B ;
SCHULTEHERMANN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9995-9999
[6]   The effect of two periods of short-term fasting during the promotion stage of hepatocarcinogenesis in rats: The role of apoptosis and cell proliferation [J].
Hikita, H ;
Vaughan, J ;
Pitot, HC .
CARCINOGENESIS, 1997, 18 (01) :159-166
[7]   THE INDUCTION OF A SPECIFIC FORM OF CYTOCHROME-P-450 (P-450J) BY FASTING [J].
HONG, JY ;
PAN, JM ;
GONZALEZ, FJ ;
GELBOIN, HV ;
YANG, CS .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (03) :1077-1083
[8]   THE ENHANCING EFFECT OF FASTING REFEEDING ON THE GROWTH OF NODULES SELECTABLE BY THE RESISTANT HEPATOCYTE MODEL IN RAT-LIVER [J].
LACONI, E ;
TESSITORE, L ;
MILIA, G ;
YUSUF, A ;
SARMA, DSR ;
TODDE, P ;
PANI, P .
CARCINOGENESIS, 1995, 16 (08) :1865-1869
[9]   THE EFFECTS OF ALTERNATING DIETARY RESTRICTION AND AD-LIBITUM FEEDING OF MICE ON THE DEVELOPMENT OF DIETHYLNITROSAMINE-INDUCED LIVER-TUMORS AND ITS CORRELATION TO INSULINEMIA [J].
LAGOPOULOS, L ;
SUNAHARA, GI ;
WURZNER, H ;
DOMBROWSKY, I ;
STALDER, R .
CARCINOGENESIS, 1991, 12 (02) :311-315
[10]   REDUCTION OF ABERRANT CRYPT FOCI INDUCED IN RAT COLON WITH AZOXYMETHANE OR METHYLNITROSOUREA BY FEEDING CHOLIC-ACID [J].
MAGNUSON, BA ;
BIRD, RP .
CANCER LETTERS, 1993, 68 (01) :15-23