Cytotoxic sesquiterpene lactones from Carpesium abrotanoides

被引：82

作者：

Lee, J

Min, B

Lee, S

Na, M

Kwon, B

Lee, C

Kim, Y

Bae, K ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon, South Korea

[3] Korea Res Inst Chem Technol, Taejon 305606, South Korea

来源：

PLANTA MEDICA | 2002年 / 68卷 / 08期

关键词：

D O I：

10.1055/s-2002-33789

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Eight sesquiterpene lactones, 4alpha,5alpha-epoxy-10alpha,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1-8 showed significant cytotoxic activity (ED50 values, < 20 muM) against all tumor call lines tested. Among these compounds, 4alpha,5alpha-epoxy-10alpha,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 muM) comparable to that of cisplatin.

引用

页码：745 / 747

页数：3

共 11 条

[1]

SESQUITERPENE LACTONES AND KAURANE GLYCOSIDES FROM FRANCOEURIA-CRISPA [J].