Octreotide in the treatment of gastrointestinal bleeding caused by angiodysplasia in two patients with von Willebrand's disease

被引：61

作者：

Bowers, M ^{[1
]}

McNulty, O ^{[1
]}

Mayne, E ^{[1
]}

机构：

[1] Royal Victoria Hosp, No Ireland Haemophilia Comprehens Care Ctr, Belfast BT12 6BA, Antrim, North Ireland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 108卷 / 03期

关键词：

von Willebrand's disease; angiodysplasia; haemorrhage; somatostatin; octreotide;

D O I：

10.1046/j.1365-2141.2000.01897.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two cases of von Willebrand's disease and angiodysplasia with intractable gastrointestinal bleeding are presented. Replacement therapy with cryoprecipitate and variable purity von Willebrand factor (VWF) was ineffective, as were other treatments including steroids, immunoglobulin and hormonal replacement. Both patients required massive blood transfusion and product support. The efficacy of somatostatin and an analogue is described. In one patient, we observed a rise in von Willebrand factor activity after octreotide infusion.

引用

页码：524 / 527

页数：4

共 19 条

[1] Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia [J].