Turnover of organelles by autophagy in yeast

被引：94

作者：

Farre, Jean-Claude ^{[2
]}

Krick, Roswitha ^{[1
]}

Subramani, Suresh ^{[2
]}

Thumm, Michael ^{[1
]}

机构：

[1] Univ Gottingen, Dept Biochem 2, D-37073 Gottingen, Germany

[2] Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, San Diego, CA 92093 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 04期

关键词：

COILED-COIL PROTEIN; SACCHAROMYCES-CEREVISIAE; PICHIA-PASTORIS; SELECTIVE AUTOPHAGY; PIECEMEAL MICROAUTOPHAGY; PEROXISOME DEGRADATION; CVT PATHWAY; MEMBRANE-STRUCTURE; PEXOPHAGY; MITOCHONDRIA;

D O I：

10.1016/j.ceb.2009.04.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Efficient detection and removal of superfluous or damaged organelles are crucial to maintain cellular homeostasis and to assure cell survival. Growing evidence shows that organelles or parts of them can be removed by selective subtypes of otherwise unselective macroautophagy and microautophagy. This requires both the adaptation of the core autophagic machinery and sophisticated mechanisms to recognize organelles destined for turnover. We review the current knowledge on autophagic removal of peroxisomes, mitochondria, ER and parts of the nucleus with an emphasis on yeasts as a model eukaryote.

引用

页码：522 / 530

页数：9

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