Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coli

被引：73

作者：

Payot, S ^{[1
]}

Avrain, L

Magras, C

Praud, K

Cloeckaert, A

Chaslus-Dancla, E

机构：

[1] INRA, UR086 BioAgresseurs, F-37380 Nouzilly, France

[2] Unite Mycoplasmol Bacteriol, Agence Francaise Secur Sanitarire Aliments, F-22440 Ploufragan, France

[3] Ecole Natl Vet SECALIM, Unite Mixte Rech, INRA, F-44307 Nantes, France

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 23卷 / 05期

关键词：

Campylobacter; fluoroquinolone; erythromycin; mutation; efflux; inhibitor;

D O I：

10.1016/j.ijantimicag.2003.12.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Thirty-eight avian and swine French isolates of Campylobacter coli were studied for their mechanisms of co-resistance to fluoroquinolones and erythromycin. A Thr86Ile modification of GyrA, responsible for fluoroquinolone resistance, was found in all the strains. Two different levels of resistance to erythromycin (MIC of 8-16 or greater than or equal to256 mg/l) were observed. A A2075G mutation in the 23S rRNA genes was found only in the highly-resistant strains. Phe-Arg-beta-naphthylamide, an efflux pump inhibitor, potentiated erythromycin in all the strains examined but restored susceptibility only in the strains with a low-level of resistance. This suggests the involvement of efflux in intrinsic and in acquired low-level of resistance to erythromycin in C. coli. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：468 / 472

页数：5

共 30 条

[1]

Avrain L., 2001, British Poultry Science, V42, pS32

[2] Single or double mutational alterations of GyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli [J].