Estrogen and bone: have we completed a full circle?

被引：4

作者：

de Villiers, T. J. ^{[1
,2
]}

机构：

[1] Mediclin Panorama, Int Menopause Soc, ZA-7500 Cape Town, South Africa

[2] Univ Stellenbosch, Dept Obstet & Gynecol, Cape Town, South Africa

来源：

CLIMACTERIC | 2014年 / 17卷

关键词：

BONE; ESTROGEN; OSTEOPOROSIS; OSTEOPENIA; ANTI-FRACTURE EFFICACY; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; HORMONE-THERAPY; MINERAL DENSITY; PLUS PROGESTIN; FRACTURE; RISK; OSTEOPOROSIS; PREVENTION; BENEFITS;

D O I：

10.3109/13697137.2014.953047

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Estrogen therapy was considered first-line therapy for the prevention and treatment of postmenopausal osteoporosis in 1984. Evidence from a large, randomized clinical trial in 2002 proved the efficacy of estrogen in the prevention of all types of osteoporosis-related fractures. Ironically, estrogen was relegated to second-line therapy, based on perceived safety concerns. The historical background to these decisions is presented. It is argued that this decision is not a reasonable reflection of the available evidence, especially in comparison to other available drugs

引用

页码：4 / 7

页数：4

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