Development and evaluation of pluronic- and methylcellulose-based thermoreversible drug delivery system for insulin

被引：14

作者：

Nasir, Fazli ^{[1
]}

Iqbal, Zafar ^{[1
]}

Khan, Amirzada ^{[1
]}

Khan, Jamshaid A. ^{[1
]}

Khan, Abad ^{[1
]}

Khuda, Fazli ^{[1
]}

Zakir, Shahida ^{[2
]}

Yousaf, Nageen ^{[3
]}

Khan, Ismail ^{[1
]}

Shah, Yasar ^{[1
]}

Khan, Muhammad Imran ^{[1
]}

Shahbaz, Naila ^{[1
]}

机构：

[1] Univ Peshawar, Dept Pharm, Peshawar 25120, Pakistan

[2] Univ Peshawar, Dept Environm Sci, Peshawar 25120, Pakistan

[3] Khyber Girls Med Coll, Dept Biochem, Peshawar, Pakistan

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2014年 / 40卷 / 11期

关键词：

Insulin; methylcellulose; pluronics; subcutaneous; thermoreversible in-situ gels; F-127; GELS; RELEASE; ABSORPTION; DIFFUSION; LIDOCAINE;

D O I：

10.3109/03639045.2013.831441

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The objective of the current work was to develop and evaluate thermoreversible subcutaneous drug delivery system for Insulin. Thermoreversible in-situ gel system was developed and evaluated both in-vitro and in-vivo comprising of pluronic F-127 alone or in combination with methylcellulose in different ratios. The drug release kinetics and mechanism was predicted by applying various mathematical models to the in-vitro dissolution data. Rabbits were used as animal model following subcutaneous injection to predict various pharmacokinetic parameters by applying Pk-Summit (R) software. The in-vitro and in-vivo data revealed that the formulation IPM 15/3 consisting of the pluronic F-127 (15% w/v) and methylcellulose (3% w/v) was the most robust and capable formulation for extending the drug release and maintaining basal plasma insulin level between 10 and 40 mu U/ml for 240 h (10 d).

引用

页码：1503 / 1508

页数：6

共 28 条

[1]

Enhanced rectal absorption of insulin-loaded Pluronic® F-127 gels containing unsaturated fatty acids [J].