The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials

被引：34

作者：

Clark, K. ^{[1
]}

Lam, L. T. ^{[2
]}

Gibson, S. ^{[3
]}

Currow, D. ^{[4
]}

机构：

[1] Univ Notre Dame, Cunningham Ctr Palliat Care, Darlinghurst, NSW, Australia

[2] Univ Notre Dame, Sch Med Sydney, Darlinghurst, NSW, Australia

[3] Royal Prince Alfred Hosp, Dept Anaesthet, Camperdown, NSW 2050, Australia

[4] Flinders Univ S Australia, So Adelaide Palliat Care Serv, Dawpark, SA, Australia

来源：

ANAESTHESIA | 2009年 / 64卷 / 06期

关键词：

ELECTIVE SURGERY; GASTROESOPHAGEAL-REFLUX; CLINICAL-TRIALS; ACID-SECRETION; FLUID PROPERTY; OMEPRAZOLE; LANSOPRAZOLE; ASPIRATION; EFFICACY; PANTOPRAZOLE;

D O I：

10.1111/j.1365-2044.2008.05861.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Aspiration of acid into the lungs is an infrequent but potentially devastating complication of general anaesthesia. Routine practice often includes use of pharmacological agents to reduce gastric volume and increase gastric pH. The aim of this study was to compare the net benefit of proton pump inhibitors with histamine 2 blockers in a meta-analysis. Electronic databases were searched for trials that compared ranitidine vs proton pump inhibitors in their effect on volume and pH of gastric fluid aspirates. We identified nine trials of which seven were suitable for meta-analysis. Pooled outcomes suggest that premedication with ranitidine is more effective than proton pump inhibitors in reducing the volume of gastric secretions (by an average of 0.22 ml.kg(-1); 95% confidence interval 0.04-0.41) and increasing gastric pH (by an average of 0.85 pH units; 95% confidence interval -1.14 to -0.28).

引用

页码：652 / 657

页数：6

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