Long-term cognitive impact of anticholinergic medications in older adults

被引：69

作者：

Bottiggi, Kara A.

Salazar, Juan C.

Yu, Lei

Caban-Holt, Allison M.

Ryan, Melody

Mendiondo, Marta S.

Schmitt, Frederick A.

机构：

[1] Univ Kentucky, Grad Ctr Gerontol, Dept Stat, Lexington, KY USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Pharm Practice, Lexington, KY 40536 USA

[4] Univ Kentucky, Dept Sci & Neurol, Lexington, KY 40536 USA

[5] Univ Kentucky, Dept Biostat, Lexington, KY 40536 USA

[6] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA

[7] Univ Kentucky, Dept Psychiat, Lexington, KY 40536 USA

[8] Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA

[9] Univ Kentucky, Dept Behav Sci, Lexington, KY 40506 USA

[10] Univ Nacl Colombia, Medellin, Colombia

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2006年 / 14卷 / 11期

关键词：

anticholinergic; normal aging; cognition; older adults;

D O I：

10.1097/01.JGP.0000224619.87681.71

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: The objective of this study was to determine whether chronic use of medications with anticholinergic (AC) properties impact older adults' cognitive functioning. Methods: Six years of cognitive test data from two groups of older adults (AC and control) were examined retrospectively (N = 592). Rcsuits: Declines over time were found for the AC group on parts A and B of the Trail Making Test. Conclusion: Physicians prescribing ACs to older adult patients should be aware of their potential effects on psychomotor speed and executive functioning. These cognitive effects may lead to impairments in daily functioning resulting in the need to reevaluate patient medications.

引用

页码：980 / 984

页数：5

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