Human serum albumin-mediated stereodifferentiation in the triplet state behavior of (S)- and (R)-Carprofen

被引：94

作者：

Lhiaubet-Vallet, V ^{[1
]}

Sarabia, Z ^{[1
]}

Boscá, F ^{[1
]}

Miranda, MA ^{[1
]}

机构：

[1] Univ Politecn Valencia, Inst Tecnol Quim, CSIC, Valencia 46022, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 31期

关键词：

D O I：

10.1021/ja048518g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A remarkable stereodifferentiation has been observed in the interaction between the excited triplet state of carprofen (CP) and human serum albumin (HSA). Time-resolved measurements using laser flash photolysis reveal the presence of two components with different lifetimes in triplet decay. This is explained by complexation of CP to the two possible HSA binding sites. The shorter-lived components are ascribed to the CP/HSA complexes in site I, where stereodifferentiation is more important (τR/τS ca. 4). This is correlated with formation of a dehalogenated photoproduct upon steady-state photolysis. Copyright © 2004 American Chemical Society.

引用

页码：9538 / 9539

页数：2

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