Plasma protein C levels in patients with acute lung injury: Prognostic significance

被引：41

作者：

Matthay, MA ^{[1
]}

Ware, LB

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Anesthesia, San Francisco, CA 94143 USA

[3] Vanderbilt Univ, Sch Med, Dept Med, Div Allergy Pulm & Crit Care Med, Nashville, TN USA

来源：

CRITICAL CARE MEDICINE | 2004年 / 32卷 / 05期

关键词：

acute lung injury; acute respiratory distress syndrome; protein C; sepsis;

D O I：

10.1097/01.CCM.0000126121.56990.D3

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Decreased circulating protein C is a marker of a prothrombotic state that has been associated with poor clinical outcomes in sepsis. However, protein C has not been measured in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). In this study, we measured circulating and intra-alveolar concentrations of protein C in 45 patients with ALI/ARDS from septic and nonseptic causes. Plasma protein C levels were lower in ALI/ARDS compared with normal controls. Lower levels of plasma protein C were associated with worse clinical outcomes, including death, fewer ventilator-free days, and more nonpulmonary organ failures, even when only patients without sepsis were analyzed. In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a therapeutic target in patients with ALI/ARDS.

引用

页码：S229 / S232

页数：4

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