Lipid, sugar and liposaccharide based delivery systems 2

被引：40

作者：

Blanchfield, J ^{[1
]}

Toth, I ^{[1
]}

机构：

[1] Univ Queensland, Sch Mol & Microbial Sci, St Lucia, Qld 4072, Australia

来源：

CURRENT MEDICINAL CHEMISTRY | 2004年 / 11卷 / 17期

关键词：

lipid; sugar; liposaccharide; drug delivery;

D O I：

10.2174/0929867043364621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vast majority of biologically active compounds will never be considered as potential drugs due to inherently poor bioavailability. This review discusses the progress in the development of chemical systems to improve the metabolic stability, absorption and physicochemical properties of potential drugs. Delivery systems that involve the conjugation of lipid and/or sugar moieties are highlighted, as well as novel methods of conjugation of these groups to drugs. The use of sugar molecules to target drugs to particular organs or cells is also discussed, as is the use of lipids in the growing area of gene delivery. This is an update of a previous review [1].

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收藏

页码：2375 / 2382

页数：8

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