2-(2-hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

被引：32

作者：

Mackman, RL ^{[1
]}

Hui, HC ^{[1
]}

Breitenbucher, JG ^{[1
]}

Katz, BA ^{[1
]}

Luong, C ^{[1
]}

Martelli, A ^{[1
]}

McGee, D ^{[1
]}

Radika, K ^{[1
]}

Sendzik, M ^{[1
]}

Spencer, JR ^{[1
]}

Sprengeler, PA ^{[1
]}

Tario, J ^{[1
]}

Verner, E ^{[1
]}

Wang, J ^{[1
]}

机构：

[1] Celera, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00311-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2019 / 2022

页数：4

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