Nucleotide sequence of the blaRTG-2 (CARB-5) gene and phylogeny of a new group of carbenicillinases

被引:23
作者
Choury, D
Szajnert, MF
Joly-Guillou, ML
Azibi, K
Delpech, M
Paul, G
机构
[1] UFR Cochin Port Royal, Lab Biol Mol Cellules Eucaryotes, F-75014 Paris, France
[2] UFR Cochin Port Royal, INSERM U129, F-75014 Paris, France
[3] UFR Cochin Port Royal, Lab Rech Microbiol, F-75014 Paris, France
[4] UFR Xavier Bichat, F-75018 Paris, France
关键词
D O I
10.1128/AAC.44.4.1070-1074.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We determined the nucleotide sequence of the bla gene for the Acinetobacter calcoaceticus beta-lactamase previously described as CARB-5. Alignment of the deduced amino acid sequence with those of known beta-lactamases revealed that CARB-5 possesses an RTG triad in box VII, as described for the Proteus mirabilis GN79 enzyme, instead of the RSG consensus characteristic of the other carbenicillinases. Phylogenetic studies showed that these RTG enzymes constitute a new, separate group, possibly ancestors of the carbenicillinase family.
引用
收藏
页码:1070 / 1074
页数:5
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