Optobionic vision-a new genetically enhanced light on retinal prosthesis

被引：90

作者：

Degenaar, Patrick ^{[1
,2
]}

Grossman, Nir ^{[1
,2
]}

Memon, Muhammad Ali ^{[1
,2
]}

Burrone, Juan ^{[3
]}

Dawson, Martin ^{[4
]}

Drakakis, Emmanuel ^{[5
]}

Neil, Mark ^{[6
]}

Nikolic, Konstantin ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Div Neurosci, London SW7 2AZ, England

[3] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England

[4] Univ Strathclyde, Inst Photon, Glasgow G4 0NW, Lanark, Scotland

[5] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

[6] Univ London Imperial Coll Sci Technol & Med, Dept Phys, London SW7 2AZ, England

来源：

JOURNAL OF NEURAL ENGINEERING | 2009年 / 6卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

VISUAL FUNCTION; CELLS; CHANNELRHODOPSIN-2; TRANSPLANTATION; STIMULATION; MELANOPSIN; EXPRESSION; RHODOPSIN; CHANNELS; MICE;

D O I：

10.1088/1741-2560/6/3/035007

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The recent discovery that neurons call be photostimulated via genetic incorporation of artificial opsins is creating a revolution in the field of neural stimulation. In this paper we show its potential in the field of retinal prosthesis. We show that we need typically 100 mW cm(-2) in instantaneous light intensity on the neuron in order to stimulate action potentials. We also show how this can be reduced down to safe levels in order to negate thermal and photochromic damage to the eye. We also describe a gallium nitride LED light Source which is also able to generate patterns of the required intensity in order to transfer reliable images.

引用

页数：10

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