Synthesis of the ABC ring system of azaspiracid.: 2.: A systematic study into the effect of C16 and C17 substitution on bis-spirocyclization

被引：27

作者：

Carter, RG ^{[1
]}

Graves, DE

Gronemeyer, MA

Tschumper, GS

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

[2] Univ Mississippi, Dept Chem & Biochem, University, MS 38677 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 13期

关键词：

D O I：

10.1021/ol026034o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A systematic study into the effect of C-16 and C-17 Substitution on the stereochemical outcome of bis-spirocyclization to form the ABC ring system of azaspiracid is disclosed. Successful construction of the natural 10R,13R bis-spirocyclic stereochemistry has been accomplished on the C-16 benzyloxy-containing precursor.

引用

收藏

页码：2181 / 2184

页数：4

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