CD4 T cells inhibit the CD8 T cell response during low-dose virus infection

被引：4

作者：

Cose, Stephen ^{[1
]}

Brammer, Clair ^{[1
]}

Zammit, David J. ^{[1
]}

Blair, D. A. ^{[1
]}

Lefrancois, Leo ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Immunol, Farmington, CT 06030 USA

来源：

INTERNATIONAL IMMUNOLOGY | 2006年 / 18卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CD4 T cells; cellular immunology; immune responses; vesicular stomatitis virus;

D O I：

10.1093/intimm/dxl061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of vesicular stomatitis virus. This finding is in contrast to the established observations that at high antigen loads CD4 T cells play little role in generating CD8 T cell responses, and that in non-infectious model systems CD4 T cells actually help the CD8 T cell response. Our results suggest that at low infectious doses, CD4 T cells play a much larger role in controlling infections than previously appreciated.

引用

页码：1285 / 1293

页数：9

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