Glutathione: Overview of its protective roles, measurement, and biosynthesis

被引：1901

作者：

Forman, Henry Jay ^{[1
]}

Zhang, Hongqiao ^{[1
]}

Rinna, Alessandra ^{[1
]}

机构：

[1] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2009年 / 30卷 / 1-2期

关键词：

Glutathione; Glutamate cysteine ligase; Hydroperoxide; Xenobiotic; Methods; GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; GLUTAMATE-CYSTEINE LIGASE; ELECTROPHILE-RESPONSE-ELEMENT; PERFORMANCE LIQUID-CHROMATOGRAPHY; ALVEOLAR EPITHELIAL-CELLS; INDUCED OXIDATIVE STRESS; MOLECULAR-MECHANISM; HYPOCHLOROUS ACID; RAT LUNG; TRANSFERASE TRANSPEPTIDASE;

D O I：

10.1016/j.mam.2008.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles in protecting cells from oxidative damage and the toxicity of xenobiotic electrophiles. and maintaining redox homeostasis. Here, the functions and GSH and the sources of oxidants and electrophiles, the elimination of oxidants by reduction and electrophiles by conjugation with GSH are briefly described. Methods of assessing GSH status in the cells are also described. GSH synthesis and its regulation are addressed along with therapeutic approaches for manipulating GSH content that have been proposed. The purpose here is to provide a brief overview of some of the important aspects of glutathione metabolism as part of this special issue that will provide a more comprehensive review of the state of knowledge regarding this essential molecule. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1 / 12

页数：12

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