Computational model of the fluid dynamics in systemic-to-pulmonary shunts

被引:49
作者
Migliavacca, F
Dubini, G
Pennati, G
Pietrabissa, R
Fumero, R
Hsia, TY
de Leval, MR
机构
[1] Great Ormond St Hosp Children NHS Trust, Cardiothorac Unit, London WC1N 3JH, England
[2] Politecn Milan, Dept Energet, I-20133 Milan, Italy
[3] Politecn Milan, Dept Bioengn, I-20133 Milan, Italy
关键词
congenital heart disease; finite element method; pressure-flow relationship; mathematical model;
D O I
10.1016/S0021-9290(99)00219-5
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A systemic-to-pulmonary shunt is a connection created between the systemic and pulmonary arterial circulations in order to improve pulmonary perfusion in children with congenital heart diseases. Knowledge of the relationship between pressure and flow in this new, surgically created, cardiovascular district may be helpful in the clinical management of these patients, whose survival is critically dependent on the blood flow distribution between the pulmonary and systemic circulations. In this study a group of three-dimensional computational models of the shunt have been investigated under steady-state and pulsatile conditions by means of a finite element analysis. The model is used to quantify the effects of shunt diameter (D), curvature, angle, and pulsatility on the pressure-flow (AP-Q) relationship of the shunt. Size of the shunt is the main regulator of pressure-Bow relationship. Innominate arterial diameter and angles of insertion have less influence. Curvature of the shunt results in lower pressure drops. Inertial effects can be neglected. The: following simplified formulae are derived: Delta P = (0.097Q + 0.521Q(2))/D-4 and Delta P = (0.096Q + 0.393Q(2))/D-4 for the different shunt geometries investigated (straight and curved shunts, respectively), (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:549 / 557
页数:9
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