Forefront of Na+/Ca2+ exchanger studies:: Stoichiometry of cardiac Na+/Ca2+ exchanger;: 3:1 or 4:1?

被引：18

作者：

Hinata, M ^{[1
]}

Kimura, J ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Pharmacol, Fukushima 9601295, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2004年 / 96卷 / 01期

关键词：

Na+/Ca2+ exchanger (NCX); stoichiometry; cardiac myocyte;

D O I：

10.1254/jphs.FMJ04002X3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stoichiometry of the Na+/Ca2+ exchanger (NCX) had been generally accepted as 3 Na+:1 Ca2+. However, recently a challenging stoichiometry of 4:1 was proposed. Therefore, using guinea pig ventricular cells, we re-examined the stoichiometry by measuring the reversal potential of the NCX current and intracellular Ca2+ concentrations under the whole-cell voltage clamp. We confirmed that the stoichiometry of NCX is 3:1 not 4:1. In addition, we explored the possible reasons for obtaining erroneous results of a 4:1 stoichiometry.

引用

页码：15 / 18

页数：4

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