Granulocyte macrophage colony-stimulating factor as an adjuvant for hepatitis B vaccination of healthy adults

被引:26
作者
Hasan, MS
Agosti, JM
Reynolds, KK
Tanzman, E
Treanor, JJ
Evans, TG
机构
[1] Univ Rochester, Sch Med & Dent, Infect Dis Unit, Rochester, NY USA
[2] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY USA
[3] Immunex Corp, Seattle, WA USA
关键词
D O I
10.1086/315129
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Granulocyte macrophage colony-stimulating factor (GM-CF) has shown promise as an adjuvant to improve the kinetics and magnitude of the immune response after vaccination. It was hypothesized that GM-CSF given intramuscularly (IM) with hepatitis B vaccine would result in increased seroconversion rates and antibody titers, In total, 108 healthy volunteers (18-45 years old) received recombinant hepatitis B vaccine IM at 0, 1, and 6 months and were randomized to receive either concurrent GM-CSF (80 or 250 pg) or placebo IM with the first two vaccinations. The percentages of subjects achieving a protective level of antibody at day 56 were 58.3%, 58.8%, and 58.3% in the placebo and 80- and 250-mu g GM-CSF arms, respectively. The geometric mean titers of antibody measured on days 28, 56, and 189 were not statistically different between arms. GM-CSF given immediately before recombinant hepatitis B vaccination was safe and well tolerated but did not appear to provide significant adjuvant activity at this dose.
引用
收藏
页码:2023 / 2026
页数:4
相关论文
共 15 条
[1]  
Ahlers JD, 1997, J IMMUNOL, V158, P3947
[2]   Prediction of response to hepatitis B vaccine in health care workers: Whose titers of antibody to hepatitis B surface antigen should be determined after a three-dose series, and what are the implications in terms of cost-effectiveness? [J].
Alimonos, K ;
Nafziger, AN ;
Murray, J ;
Bertino, JS .
CLINICAL INFECTIOUS DISEASES, 1998, 26 (03) :566-571
[3]  
Allison AC, 1998, DEV BIOL STAND, V92, P3
[4]   Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children [J].
Chang, MH ;
Chen, CJ ;
Lai, MS ;
Hsu, HM ;
Wu, TC ;
Kong, MS ;
Liang, DC ;
Shau, WY ;
Chen, DS .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (26) :1855-1859
[5]  
Disis ML, 1996, BLOOD, V88, P202
[6]  
FISCHER HG, 1988, J IMMUNOL, V141, P3882
[7]   LONG-TERM IMMUNOGENICITY AND EFFICACY OF HEPATITIS-B VACCINE IN HOMOSEXUAL MEN [J].
HADLER, SC ;
FRANCIS, DP ;
MAYNARD, JE ;
THOMPSON, SE ;
JUDSON, FN ;
ECHENBERG, DF ;
OSTROW, DG ;
OMALLEY, PM ;
PENLEY, KA ;
ALTMAN, NL ;
BRAFF, E ;
SHIPMAN, GF ;
COLEMAN, PJ ;
MANDEL, EJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (04) :209-214
[8]   The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on hepatitis B vaccination in haemodialysis patients [J].
Hess, G ;
Kreiter, F ;
Kosters, W ;
Deusch, K .
JOURNAL OF VIRAL HEPATITIS, 1996, 3 (03) :149-153
[9]   Delivery of cytokines by liposomes .3. Liposome-encapsulated GM-CSF and TNF-alpha show improved pharmacokinetics and biological activity and reduced toxicity in mice [J].
Kedar, E ;
Palgi, O ;
Golod, G ;
Babai, I ;
Barenholz, Y .
JOURNAL OF IMMUNOTHERAPY, 1997, 20 (03) :180-193
[10]   GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PROMOTES DIFFERENTIATION AND SURVIVAL OF HUMAN PERIPHERAL-BLOOD DENDRITIC CELLS-INVITRO [J].
MARKOWICZ, S ;
ENGLEMAN, EG .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (03) :955-961