Analysis of cis-trans isomers and enantiomers of sertraline by cyclodextrin-modified micellar electrokinetic chromatography

被引：41

作者：

Lucangioli, SE

Hermida, LG

Tripodi, VP

Rodríguez, VG

López, EE

Rouge, PD

Carducci, CN

机构：

[1] Univ Buenos Aires, Fac Pharm & Biochem, Dept Analyt Chem & Physicochem, RA-1113 Buenos Aires, DF, Argentina

[2] Natl Inst Ind Technol, RA-1650 Buenos Aires, DF, Argentina

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 871卷 / 1-2期

关键词：

enantiomer separation; sertraline; cyclodextrins;

D O I：

10.1016/S0021-9673(99)00881-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work development, optimization and validation of a cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) method is proposed to resolve separation of the sertraline hydrochloride and synthesis-related substances. Sertraline hydrochloride, the cis-(1S,4S) enantiomer form, is used as an antidepressant therapeutic agent. A. buffer concentration composed of 20 mM sodium berate, pH 9.0 with 50 mM sodium cholate, 15 mM sulfated beta-cyclodextrin and 5 mM hydroxypropyl-beta-cyclodextrin was found to be the most suitable background electrolyte. Quantitation of the impurities at levels of 0.1% in different samples of the bulk drug was determined. A comparison of the results with those obtained by HPLC methodology was also accomplished. The method proved appropriate for testing the purity of sertraline hydrochloride in bulk drug. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：207 / 215

页数：9

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