A new cytotoxic polychlorinated sulfolipid from contaminated Adriatic mussels

被引:38
作者
Ciminiello, P
Dell'Aversano, C
Fattorusso, E
Forino, M
Magno, S
Di Meglio, P
Ianaro, A
Poletti, R
机构
[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[2] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy
[3] Ctr Rid Marine, I-47042 Cesenatico, FC, Italy
关键词
polychlorinated sulfolipid; marine biotoxin; toxic Adriatic mussels;
D O I
10.1016/j.tet.2003.12.072
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A detailed analysis of toxic shellfish collected in the Adriatic sea in October 2000 allowed us to isolate a new cytotoxic chlorosulfolipid (3). Its gross structure has been elucidated through an extensive NMR analysis including various 2D techniques; the relative stereochemistry has been solved by applying the Murata's method. Compound 3 showed to posses cytotoxic activity against WEHI 164 and J774 cells. The presence of chlorosulfolipids in toxic mussels from the northern Adriatic sea has not to be considered incidental as we have been detecting these cytotoxic compounds since 1998. Their simultaneous and constant presence together with typical marine biotoxins represents a further risk both to consumers' health and aquacultures economic proceeds. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:7093 / 7098
页数:6
相关论文
共 14 条