Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

被引：400

作者：

Basile, David P. ^{[1
,2
]}

Bonventre, Joseph V. ^{[3
]}

Mehta, Ravindra ^{[4
]}

Nangaku, Masaomi ^{[5
]}

Unwin, Robert ^{[6
]}

Rosner, Mitchell H. ^{[7
,8
]}

Kellum, John A. ^{[9
]}

Ronco, Claudio ^{[10
,11
]}

机构：

[1] Indiana Univ, Dept Cellular & Integrat Physiol, Indianapolis, IN 46204 USA

[2] Indiana Univ, Dept Med, Div Nephrol, Indianapolis, IN 46204 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Renal Div,Dept Med, Boston, MA USA

[4] Univ Calif San Diego, Dept Med, Div Nephrol & Hypertens, San Diego, CA 92103 USA

[5] Univ Tokyo, Grad Sch Med, Div Nephrol & Endocrinol, Tokyo, Japan

[6] UCL, Ctr Nephrol, Div Med, London, England

[7] Univ Virginia, Dept Med, Div Nephrol, Charlottesville, VA USA

[8] Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USA

[9] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Ctr Crit Care Nephrol,Clin Res Invest & Syst Mode, Pittsburgh, PA USA

[10] San Bortolo Hosp, Dept Nephrol Dialysis & Transplantat, Vicenza, Italy

[11] Int Renal Res Inst, Vicenza, Italy

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2016年 / 27卷 / 03期

关键词：

ACUTE KIDNEY INJURY; RENAL ISCHEMIA-REPERFUSION; CELL-CYCLE ARREST; UNILATERAL URETERAL OBSTRUCTION; LONG-TERM FUNCTION; ENHANCES RECOVERY; CARDIAC-SURGERY; WARM ISCHEMIA; DISEASE; FIBROSIS;

D O I：

10.1681/ASN.2015030309

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarding the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled "Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury" convened in April of 2014 and assigned a working group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, including an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.

引用

页码：687 / 697

页数：11

共 79 条

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Clinical factors associated with initiation of renal replacement therapy in critically ill patients with acute kidney injury-A prospective multicenter observational study [J].