Cardiovascular toxicities of immunosuppressive agents

被引：366

作者：

Miller, LW ^{[1
]}

机构：

[1] Univ Minnesota, Div Cardiovasc, Minneapolis, MN 55455 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2002年 / 2卷 / 09期

关键词：

cardiovascular toxicity; immunosuppressants; organ transplantation;

D O I：

10.1034/j.1600-6143.2002.20902.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Cardiovascular disease is one of the major causes of morbidity and mortality following solid organ transplantation. Many of the current immunosuppressive drugs are associated with an increase of one or more risk factors for the development of atherosclerosis. This review compares the mechanism by which individual immunosuppressive agents may impact on these risk factors and the differential contribution of cyclosporine, tacrolimus, mycophenolate, azathioprine, and Rapamycin to these individual risk factors. Attention to the potential cardiovascular toxicities of individual immunosuppressive agents may help design strategies for maintenance of immunosuppression tailored to individual patients.

引用

页码：807 / 818

页数：12

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