Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes

被引：57

作者：

Satoh, K ^{[1
]}

Nagano, Y ^{[1
]}

Shimomura, C ^{[1
]}

Suzuki, N ^{[1
]}

Saeki, Y ^{[1
]}

Yokota, H ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, Discovery Res Lab, Tokyo R&D Ctr, Edogawa Ku, Tokyo 1348630, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 283卷 / 03期

关键词：

beta-amyloid; Alzheimer's disease; prostaglandin E-2; rat astrocyte; cDNA subtraction;

D O I：

10.1016/S0304-3940(00)00926-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Deposition of beta-amyloid (A beta) in the brain is considered to be one of the most critical events in the onset of Alzheimer's disease (AD). In order to identify factors involved in the exacerbation of AD, we investigated transcriptionally Ap-induced genes using a cDNA subtraction technique in rat astrocytes. One gene obtained was rat prostaglandin (PG) E synthase. In this report, we present the deduced sequence for rat PGE synthase for the first time and demonstrate the induction of PGE synthase mRNA by treatment of cells with A beta. Our results suggest a possibly significant role of this enzyme in the progression of AD. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：221 / 223

页数：3

共 23 条

[1]

DO NONSTEROIDAL ANTIINFLAMMATORY DRUGS DECREASE THE RISK FOR ALZHEIMERS-DISEASE - THE ROTTERDAM STUDY [J].

ANDERSEN, K ;

LAUNER, LJ ;

OTT, A ;

HOES, AW ;

BRETELER, MMB ;

HOFMAN, A .

NEUROLOGY, 1995, 45 (08) :1441-1445

[2]

INVERSE ASSOCIATION OF ANTIINFLAMMATORY TREATMENTS AND ALZHEIMERS-DISEASE - INITIAL RESULTS OF A COTWIN CONTROL STUDY [J].

BREITNER, JCS ;

GAU, BA ;

WELSH, KA ;

PLASSMAN, BL ;

MCDONALD, WM ;

HELMS, MJ ;

ANTHONY, JC .

NEUROLOGY, 1994, 44 (02) :227-232

[3]

Cotman CW, 1996, NEUROBIOL AGING, V17, P723

[4]

The pathogenesis of senile plaques [J].

Dickson, DW .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (04) :321-339

[5]

Cyclooxygenase in biology and disease [J].

Dubois, RN ;

Abramson, SB ;

Crofford, L ;

Gupta, RA ;

Simon, LS ;

Van De Putte, LBA ;

Lipsky, PE .

FASEB JOURNAL, 1998, 12 (12) :1063-1073

[6]

MOLECULAR PROFILE OF REACTIVE ASTROCYTES - IMPLICATIONS FOR THEIR ROLE IN NEUROLOGIC DISEASE [J].

EDDLESTON, M ;

MUCKE, L .

NEUROSCIENCE, 1993, 54 (01) :15-36

[7]

MOLECULAR MECHANISMS OF SLEEP-WAKE REGULATION - ROLES OF PROSTAGLANDIN-D2 AND PROSTAGLANDIN-E2 [J].

HAYAISHI, O .

FASEB JOURNAL, 1991, 5 (11) :2575-2581

[8]

Prostaglandin synthase 2 [J].

Herschman, HR .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1299 (01) :125-140

[9]

ALTERATIONS IN NOCICEPTION AFTER INTRACISTERNAL ADMINISTRATION OF PROSTAGLANDIN-D2, E2 OR F2-ALPHA TO CONSCIOUS MICE [J].

HORIGUCHI, S ;

UENO, R ;

HYODO, M ;

HAYAISHI, O .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 122 (02) :173-179

[10]

Amyloid-β peptide activates cultured astrocytes:: morphological alterations, cytokine induction and nitric oxide release [J].

Hu, JG ;

Akama, KT ;

Krafft, GA ;

Chromy, BA ;

Van Eldik, LJ .

BRAIN RESEARCH, 1998, 785 (02) :195-206

← 1 2 3 →