Effect of antiandrogens casodex and epitestosterone on bone composition in mice

被引:16
作者
Broulik, PD
Starka, L
机构
[1] INST ENDOCRINOL,PRAGUE,CZECH REPUBLIC
[2] CHARLES UNIV,FAC MED 1,MED CLIN 3,PRAGUE,CZECH REPUBLIC
关键词
casodex; epitestosterone; antiandrogens; bone mineral content; bone density;
D O I
10.1016/S8756-3282(97)00012-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nonsteroidal antiandrogen casodex and steroidal antiandrogen epitestosterone were administered to intact male mice, and their effect on femoral bones and circulating calcium, phosphate, testosterone, and LH were compared with controls and castrated animals, Pure antiandrogen casodex in a dose used in humans for treatment of prostate cancer decreased the weight of seminal vesicles, organ which is highly sensitive to the androgenic effect, increased insignificantly the concentration of LH and of testosterone, but did not have any effect on bone density or mineral content of bone, Epitestosterone, which not only inhibits the binding of androgens to their receptors but also inhibits the formation of dihydrotestosterone from testosterone, and is reported to interfere with aromatization of testosterone to estrogens, decreased the bone density, ash weight, and calcium and phosphate content of femoral bone tissue significantly, although not to values as low as those seen in castrated animals. (C) 1997 by Elsevier Science Inc.
引用
收藏
页码:473 / 475
页数:3
相关论文
共 21 条
[1]  
BROULIK PD, 1976, ENDOCRINOL EXP, V10, P211
[2]   IDENTIFICATION OF ANDROGEN RECEPTORS IN NORMAL HUMAN OSTEOBLAST-LIKE CELLS [J].
COLVARD, DS ;
ERIKSEN, EF ;
KEETING, PE ;
WILSON, EM ;
LUBAHN, DB ;
FRENCH, FS ;
RIGGS, BL ;
SPELSBERG, TC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (03) :854-857
[3]   LONG-TERM EFFECT OF ORCHIECTOMY ON CORTICAL BONE FROM RAT FEMUR - BONE MASS AND MECHANICAL-PROPERTIES [J].
DANIELSEN, CC ;
MOSEKILDE, L ;
ANDREASSEN, TT .
CALCIFIED TISSUE INTERNATIONAL, 1992, 50 (02) :169-174
[4]   MULTIPLE RANGE AND MULTIPLE F TESTS [J].
DUNCAN, DB .
BIOMETRICS, 1955, 11 (01) :1-42
[5]   A POSSIBLE EXPLANATION FOR THE PERIPHERAL SELECTIVITY OF A NOVEL NON-STEROIDAL PURE ANTIANDROGEN, CASODEX (ICI 176,334) [J].
FREEMAN, SN ;
MAINWARING, WIP ;
FURR, BJA .
BRITISH JOURNAL OF CANCER, 1989, 60 (05) :664-668
[6]   The preclinical development of bicalutamide: Pharmacodynamics and mechanism of action [J].
Furr, BJA ;
Tucker, H .
UROLOGY, 1996, 47 (1A) :13-25
[7]  
GITTELMAN HJ, 1967, ANAL BIOCHEM, V18, P521
[8]   USE OF IODINATED STEROID AS RADIOLIGAND FOR TESTOSTERONE RADIOIMMUNOASSAY [J].
HAMPL, R ;
DVORAK, P ;
LUKESOVA, S ;
KOZAK, I ;
CHRPOVA, M ;
STARKA, L .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1978, 9 (08) :771-773
[9]  
HERTEL P, 1969, ARZENEIMITTEL FORSCH, V11, P1777
[10]  
IVERSEN P, 1992, 3RD P INT S REC ADV, P120