The influenza A virus NS1 protein inhibits activation of jun N-terminal kinase and AP-1 transcription factors

被引：149

作者：

Ludwig, S

Wang, XY

Ehrhardt, C

Zheng, HY

Donelan, N

Planz, O

Pleschka, S

García-Sastre, A

Heins, G

Wolff, T

机构：

[1] Robert Koch Inst, D-13353 Berlin, Germany

[2] Univ Dusseldorf, Inst Mol Med, D-40225 Dusseldorf, Germany

[3] Bundesforsch Anstalt Viruskrankheiten Tiere, D-72076 Tubingen, Germany

[4] Univ Giessen, Inst Virol, Fachbereich Vet Med, D-35392 Giessen, Germany

[5] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[6] Mt Sinai Sch Med, Microbiol Grad Sch Training Program, New York, NY 10029 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 21期

关键词：

D O I：

10.1128/JVI.76.21.11166-11171.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.

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页码：11166 / 11171

页数：6

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