How Do You Treat Patients With Myalgia Who Take Statins?

被引：18

作者：

Siddiqi, Saadi A. ^{[1
]}

Thompson, Paul D. ^{[1
]}

机构：

[1] Hartford Hosp, Div Cardiol, Hartford, CT 06102 USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2009年 / 11卷 / 01期

关键词：

SKELETAL-MUSCLE; MYOPATHY; THERAPY; COENZYME-Q10; GEMFIBROZIL; METABOLISM; SYMPTOMS; CREATINE; EFFICACY; ACID;

D O I：

10.1007/s11883-009-0002-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are safe and effective in lowering low-density lipoprotein cholesterol. As a result, they confer an all-cause mortality benefit across a wide range of patient groups. The utility of statins is limited by their adverse effects, including myalgias and rhabdomyolysis. These clinical events, plus other symptoms, constitute what is termed statin myopathy. This review summarizes current concepts of statin myopathy and presents strategies to minimize statin-associated myopathic complaints.

引用

页码：9 / 14

页数：6

共 36 条

[1] Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance [J].

Backes, James M. ;

Venero, Carmelo V. ;

Gibson, Cheryl A. ;

Ruisinger, Janelle F. ;

Howard, Patricia A. ;

Thompson, Paul D. ;

Moriarty, Patrick M. .

ANNALS OF PHARMACOTHERAPY, 2008, 42 (03) :341-346

[2] Risk for myopathy with statin therapy in high-risk patients [J].

Ballantyne, CM ;

Corsini, A ;

Davidson, MH ;

Holdaas, H ;

Jacobson, TA ;

Leitersdorf, E ;

März, W ;

Reckless, JPD ;

Stein, EA .

ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (05) :553-564

[3] Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients -: The PRIMO study [J].

Bruckert, E ;

Hayem, G ;

Dejager, S ;

Yau, C ;

Bégaud, B .

CARDIOVASCULAR DRUGS AND THERAPY, 2005, 19 (06) :403-414

[4] Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins [J].

Caso, Giuseppe ;

Kelly, Patricia ;

McNurlan, Margaret A. ;

Lawson, William E. .

AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (10) :1409-1412

[5] SIMVASTATIN-INDUCED RHABDOMYOLYSIS FOLLOWED BY A MELAS SYNDROME [J].

CHARIOT, P ;

ABADIA, R ;

AGNUS, D ;

DANAN, C ;

CHARPENTIER, C ;

GHERARDI, RK .

AMERICAN JOURNAL OF MEDICINE, 1993, 94 (01) :109-110

[6]

Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3

[7] Statin-induced apoptosis and skeletal myopathy [J].

Dirks, Amie J. ;

Jones, Kimberly M. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2006, 291 (06) :C1208-C1212

[8] Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia [J].

Draeger, A. ;

Monastyrskaya, K. ;

Mohaupt, M. ;

Hoppeler, H. ;

Savolainen, H. ;

Allemann, C. ;

Babiychuk, E. B. .

JOURNAL OF PATHOLOGY, 2006, 210 (01) :94-102

[9] Efficacy of Rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins [J].

Gadarla, Mamatha ;

Kearns, Amy K. ;

Thompson, Paul D. .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 101 (12) :1747-1748

[10] Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid [J].

Goosen, Theunis C. ;

Bauman, Jonathan N. ;

Davis, John A. ;

Yu, Chongwoo ;

Hurst, Susan I. ;

Williams, J. Andrew ;

Loi, Cho-Ming .

DRUG METABOLISM AND DISPOSITION, 2007, 35 (08) :1315-1324

← 1 2 3 4 →