Transforming growth factor-β1 induces apoptosis via connective tissue growth factor in human aortic smooth muscle cells

被引：49

作者：

Hishikawa, K ^{[1
]}

Nakaki, T ^{[1
]}

Fujii, T ^{[1
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Pharmacol, Itabashi Ku, Tokyo 1738605, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 385卷 / 2-3期

关键词：

CTGF (connective tissue growth factor); TGF-beta(1) (transforming growth factor beta); apoptosis; caspase; antisense oligonucleotide;

D O I：

10.1016/S0014-2999(99)00763-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the possible involvement of connective tissue growth factor (CTGF) in the apoptosis induced by transforming growth factor-beta(1) (TGF-beta(1)) in human aortic vascular smooth muscle cells (HASC). in quiescent HASC, TGF-beta(1) induced the mRNA and protein of CTGF. A CTGF antisense oligonucleotide inhibited this induction. TGF-beta(1) significantly reduced cell viability and induced DNA fragmentation, and the CTGF antisense oligonucleotide reversed these effects. Moreover, TGF-beta(1) activated caspase 3 in HASC, and the CTGF antisense oligonucleotide reduced this activation. These findings show that CTGF plays a key role in the TGF-beta(1)-induced apoptosis in HASC. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：287 / 290

页数：4

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