Emerging targets in neuroinflammation-driven chronic pain

被引：782

作者：

Ji, Ru-Rong ^{[1
]}

Xu, Zhen-Zhong ^{[1
]}

Gao, Yong-Jing ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

[2] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Pain Res Lab, Inst Naut Med, Nantong 226001, Jiangsu, Peoples R China

来源：

NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 07期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

PERIPHERAL-NERVE INJURY; SPINAL-CORD ASTROCYTES; NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASE; PRIMARY SENSORY NEURONS; LONG-TERM POTENTIATION; RESOLVIN D-SERIES; NEUROPATHIC PAIN; DORSAL-HORN; INFLAMMATORY PAIN;

D O I：

10.1038/nrd4334

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role in the induction and maintenance of chronic pain. This Review focuses on emerging targets - such as chemokines, proteases and the WNT pathway - that promote spinal cord neuroinflammation and chronic pain. It also highlights the anti-inflammatory and pro-resolution lipid mediators that act on immune cells, glial cells and neurons to resolve neuroinflammation, synaptic plasticity and pain. Targeting excessive neuroinflammation could offer new therapeutic opportunities for chronic pain and related neurological and psychiatric disorders.

引用

页码：533 / 548

页数：16

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