Prestin and the cochlear amplifier

被引:98
作者
Dallos, Peter
Zheng, Jing
Cheatham, Mary Ann
机构
[1] Northwestern Univ, Dept Neurobiol & Physiol, Hugh Knowles Ctr, Inst Neurosci, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Commun Sci & Disorders, Hugh Knowles Ctr, Inst Neurosci, Evanston, IL 60208 USA
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2006年 / 576卷 / 01期
关键词
D O I
10.1113/jphysiol.2006.114652
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In non-mammalian, hair cell-bearing sense organs amplification is associated with mechanoelectric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.
引用
收藏
页码:37 / 42
页数:6
相关论文
共 66 条
[11]   THE MECHANICAL-PROPERTIES OF CILIARY BUNDLES OF TURTLE COCHLEAR HAIR-CELLS [J].
CRAWFORD, AC ;
FETTIPLACE, R .
JOURNAL OF PHYSIOLOGY-LONDON, 1985, 364 (JUL) :359-&
[12]   Prestin, a new type of motor protein [J].
Dallos, P ;
Fakler, B .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (02) :104-111
[13]   HIGH-FREQUENCY MOTILITY OF OUTER HAIR-CELLS AND THE COCHLEAR AMPLIFIER [J].
DALLOS, P ;
EVANS, BN .
SCIENCE, 1995, 267 (5206) :2006-2009
[14]   Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries [J].
Diatchenko, L ;
Lau, YFC ;
Campbell, AP ;
Chenchik, A ;
Moqadam, F ;
Huang, B ;
Lukyanov, S ;
Lukyanov, K ;
Gurskaya, N ;
Sverdlov, ED ;
Siebert, PD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :6025-6030
[15]   Piezoelectric reciprocal relationship of the membrane motor in the cochlear outer hair cell [J].
Dong, XX ;
Ospeck, M ;
Iwasa, KH .
BIOPHYSICAL JOURNAL, 2002, 82 (03) :1254-1259
[16]   Functional properties of prestin - How the motormolecule works work [J].
Fakler, B ;
Oliver, D .
BIOPHYSICS OF THE COCHLEA: FROM MOLECULES TO MODELS, 2003, :110-115
[17]   STRUCTURAL FEATURES OF THE LATERAL WALLS IN MAMMALIAN COCHLEAR OUTER HAIR-CELLS [J].
FORGE, A .
CELL AND TISSUE RESEARCH, 1991, 265 (03) :473-483
[18]  
FRANCHINI LF, 2006, IN PRESS MOL PHYLOGE
[19]   Limiting dynamics of high-frequency electromechanical transduction of outer hair cells [J].
Frank, G ;
Hemmert, W ;
Gummer, AW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4420-4425
[20]   Organ of corti potentials and the motion of the basilar membrane [J].
Fridberger, A ;
de Monvel, JB ;
Zheng, JF ;
Hu, N ;
Zou, Y ;
Ren, TY ;
Nuttall, A .
JOURNAL OF NEUROSCIENCE, 2004, 24 (45) :10057-10063